Hi Upila. From what I have read and experienced the symptoms don't go for a crap in hours or even a day that you would really notice. I have had times when one day I can work a cork screw and the next day I can't. 2 days later I can work it. Haven't been able to work a can opener for quite a while but am not a fan of canned food anyway so it wasn't a big loss. I used a skill saw last week but I had trouble holding the switch in. I could hold the weight of the saw but my finger wouldn't stay on the switch for the whole time. This disease is just plain weird. There is no telling where it will take you. Day to day is about the only advice I can give.